65 A Retrospective Cohort Study of the Use of Vivostat PRF Autologous Platelet-Rich Fibrin in Patient Outcomes in Total Knee Replacement Surgery

Abstract Aim Vivostat PRF is an autologous platelet-rich fibrin spray that prepared in theatre from the patient’s own blood and has shown its use as a biological sealant intra-operatively reduces transfusion rates decreases haemarthrosis after total knee replacement (TKR). We undertook retrospective time-based comparative cohort study examining relevant patient outcomes, comparing patients undergoing TKR surgery with versus without. Method 106 between 2008 2017 were studied. Patients selected for inclusion via hospital records divided into two groups: those who had received (n = 59), hadn’t 47) (the control group). Primary outcomes included haemoglobin drop pre- vs post-operatively, range of movement (ROM) at follow-up appointments, number days post-operatively until was able to manage stairs, post-operative pain scores rates. Results There statistically significant difference groups, 27.5g/L group compared 31.9g/L (p 0.019). ROM day 3 better by 5.0o 0.0018), months there 7.8o greater 0.004). No differences seen scores; however, early rehabilitation performance improved group, quicker time being stairs 0.04). no Conclusions This showed are benefits using surgery.